[Perineal pyoderma gangrenosum in a girl treated with adalimumab after infliximab failure].

Adalimumab Therapy for Recalcitrant Pyoderma Gangrenosum

OBJECTIVE To describe a patient with treatment-refractory pyoderma gangrenosum and the outcome of a novel therapeutic approach. METHODS Case report and review of the literature. RESULTS A patient with inflammatory bowel disease developed severe pyoderma gangrenosum while receiving treatment with the chimeric anti-TNF-alpha antibody infliximab. Despite subsequent trials of numerous immunosup...

Introducing a Case of Pyoderma Gangrenosum in the Breast

Introduction: Pyoderma gangrenosum (PG) of the breast is a rare that present as a painful ulcer on the skin. It usually affects people in their 20s to 50s and occurs in both men and women. Typically, PG affects the legs in adults. In children, it may affect the legs, buttocks, head, and neck. Pyoderma gangrenosum is characterized by a papule, nodule, or pustule that progresses to an injured les...

Recurrent pyoderma gangrenosum and cystic acne associated with leucocyte adhesion deficiency due to novel mutations in ITGB2: successful treatment with infliximab and adalimumab.

Biologics for the treatment of pyoderma gangrenosum in ulcerative colitis

Pyoderma gangrenosum (PG) is an uncommon extra-intestinal manifestation of inflammatory bowel disease (IBD). Despite limited published literature, biologics have caused a paradigm shift in the management of this difficult-to-treat skin condition. The clinical data and outcomes of three patients with active ulcerative colitis and concurrent PG treated with biologics (infliximab two and adalimuma...

The role of interleukin-1β in pyoderma gangrenosum

IL: interleukin PAPA: pyogenic arthritis, pyoderma gangrenosum, and acne PASH: pyoderma gangrenosum, acne, and suppurative hidradenitis PG: pyoderma gangrenosum TNF: tumor necrosis factor UC: ulcerative colitis INTRODUCTION Pyoderma gangrenosum (PG) is a rare, inflammatory, and necrotizing disease that belongs to the group of neutrophilic dermatosis. The pathogenesis of PG remains unknown. In t...